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Introduction The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare but severe, potentially fatal, idiosyncratic, adverse drug reaction with cutaneous and systemic manifestations ( Although it is more common in adults, the DRESS syndrome can also affect children, resulting in long-term and delayed sequelae or even death, and effectively prohibiting patients to use possibly important drugs for life ( In the present work, we report the evidence about clinical features, diagnosis, and treatment of the DRESS syndrome in children and highlight the differences between the pediatric and adult populations

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